Physiology & Pharmacology
Zolfaghar Lotfi; Alieh Safamanesh
Volume 29, Issue 3 , September and October 2022, , Pages 406-420
Abstract
Introduction: Inadequate nutrition is one of the causes of high cholesterol and blood lipid, which if untreated, due to the high inflammation of liver cells, can lead to fatty liver. The aim of this study was to evaluate the anti-hyperlipidemia effect of herbal tea of Rosa damascena Mill and Cassia angustifolia ...
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Introduction: Inadequate nutrition is one of the causes of high cholesterol and blood lipid, which if untreated, due to the high inflammation of liver cells, can lead to fatty liver. The aim of this study was to evaluate the anti-hyperlipidemia effect of herbal tea of Rosa damascena Mill and Cassia angustifolia Vahl on lipid profile in male rats.
Materials and Methods: In this experimental study, 28 male rats (220 ± 20 g) were randomly divided into four groups (n = 7 each): control, control + high-fat diet, experimental group + high-fat diet + herbal tea, and experimental group + herbal tea. The groups were treated with herbal tea of Cassia angustifolia Vahl (0.4 g/kg) plus Rosa damascena Mill (0.2 g/kg) in three time periods with two days interval. After 28 days, the animals were anesthetized, and blood samples were collected from the heart. Blood parameters were measured using an autoanalyzer.
Results: Based on the results, lipid profile, except for the AST enzyme, significantly decreased in the experimental group with high-fat diet + herbal tea. In the experimental group with normal diet + herbal tea, the profile did not show any significant difference; however, AST enzyme increased significantly (p ≤ 0.05), as compared to the control group.
Conclusion: Herbal tea prepared with a combination of Cassia angustifolia Vahl and Rosa damascena Mill can be considered as a drug with rapid efficacy in people with hyperlipidemia.